| Autor: |
Inozemtsev AN, Agapitova AE, Bokieva SB, Glazova NIu, Levitskaia NG, Kamenskiĭ AA, Miasoedov NF |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2013 Nov-Dec; Vol. 63 (6), pp. 711-8. |
| DOI: |
10.7868/s0044467713060063 |
| Abstrakt: |
Semax effects on formation of active avoidance reaction in rats in different experimental models have been studied. It was shown that intraperitoneal Semax administration at a dose of 0.05 mg/kg accelerated acquisition of one-way active avoidance response when rats were trained to avoid electric foot-shock by jumping on the shelf. When rats were trained in shuttle-box the peptide increased the electroshock threshold value required to provocation of rat moving in experimental box and delayed acquisition of two-way active avoidance response. At the same time Semax stimulated avoidance response restoration in shuttle-box after functional disturbances induced by acute modification of cause-effect and spatial relationships in experimental environment. Data obtained support nootropic properties of Semax. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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