Clastogenic effects of Trypanosoma brucei brucei and Trypanosoma evansi mixed infection in bone marrow of Wistar rats.

Autor: Habila N; Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic. 3800, Australia. Electronic address: nathanhabila@gmail.com., Muhammad A; Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria., Ndidi US; Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria., Chechet GD; Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria., Aimola IA; Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria., Olalekan BA; Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2014 Dec; Vol. 97 (3), pp. 550-3. Date of Electronic Publication: 2014 Oct 16.
DOI: 10.1016/j.rvsc.2014.09.018
Abstrakt: The clastogenic effect of mixed infection of Trypanosoma evansi and Trypanosoma brucei brucei in the bone marrow (BM) cells of Wistar albino rats was investigated. Clastogenic effects were observed in the BM cells using the micronucleus assay. The findings indicate that T. evansi, T. b. brucei and mixed infection with both parasites induced the formation of micronucleated polychromatic erythrocyte (MN-PCEs) in the BM cells significantly (P < 0.05) by 60, 63 and 81 micronuclei/1000 PCE respectively. Mixed infection induced formation of MN-PCEs increase by about 1.33 fold when compared with single infections of T. b. brucei and T. evansi. These data give a preliminary evidence of possible genotoxic effects in trypanosomiasis.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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