Leisure activities, apolipoprotein E e4 status, and the risk of dementia.

Autor:	Yang SY; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Weng PH; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Family Medicine, Taiwan Adventist Hospital, Taipei, Taiwan., Chen JH; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan., Chiou JM; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan., Lew-Ting CY; Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan., Chen TF; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Sun Y; Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan., Wen LL; Department of Laboratory Medicine, En Chu Kong Hospital, Taipei, Taiwan., Yip PK; School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan; Center of Neurological Medicine, Cardinal Tien Hospital, Taipei, Taiwan., Chu YM; Department of Laboratory Medicine, Cardinal Tien Hospital, Taipei, Taiwan., Chen YC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan; Research Center for Genes, Environment, and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address: karenchen@ntu.edu.tw.
Jazyk:	angličtina
Zdroj:	Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 2015 Dec; Vol. 114 (12), pp. 1216-24. Date of Electronic Publication: 2014 Nov 04.
DOI:	10.1016/j.jfma.2014.09.006
Abstrakt:	Background/purpose: Leisure activities have been associated with a decreased risk of dementia. However, to date, no study has explored how apolipoprotein E (ApoE) e4 status or vascular risk factors modified the association between leisure activities and dementia risks. Methods: This case-control study recruited patients (age ≥ 60 years) with Alzheimer's disease (AD; n = 292) and vascular dementia (VaD; n = 144) and healthy controls (n = 506) from three teaching hospitals in Taiwan between 2007 and 2010. Information on patient's leisure activities were obtained through a questionnaire. Conditional logistic regression models were used to assess the association of leisure activities and ApoE e4 status with the risk of dementia. Results: High-frequency physical activity was associated with a decreased risk of AD [adjusted odds ratio (AOR) = 0.45], and the results become more evident among ApoE e4 carriers with AD (AOR = 0.30) and VaD (AOR = 0.26). Similar findings were observed for cognitive (AOR = 0.42) and social activities (AOR = 0.55) for AD. High-frequency physical, cognitive, and social activities were associated with a decreased risk of VaD (AOR = 0.29-0.60). Physical and social activities significantly interacted with each other on the risk of VaD (pinteraction = 0.04). Conclusion: Physical activity consistently protects against AD and VaD. Significant interactions were identified across different types of leisure activities in lowering dementia risk. (Copyright © 2014. Published by Elsevier B.V.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu