Parkinson's disease as a member of Prion-like disorders.

Autor: Herva ME; The Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: meh67@cam.ac.uk., Spillantini MG; The Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, UK.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2015 Sep 02; Vol. 207, pp. 38-46. Date of Electronic Publication: 2014 Nov 04.
DOI: 10.1016/j.virusres.2014.10.016
Abstrakt: Parkinson's disease is one of several neurodegenerative diseases associated with a misfolded, aggregated and pathological protein. In Parkinson's disease this protein is alpha-synuclein and its neuronal deposits in the form of Lewy bodies are considered a hallmark of the disease. In this review we describe the clinical and experimental data that have led to think of alpha-synuclein as a prion-like protein and we summarize data from in vitro, cellular and animal models supporting this view.
(Copyright © 2014. Published by Elsevier B.V.)
Databáze: MEDLINE
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