Endocrine changes in histiocytosis of the hypothalamic-pituitary axis.

Autor:	Toro Galván S; Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España. Electronic address: storo@bellvitgehospital.cat., Planas Vilaseca A; Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España., Michalopoulou Alevras T; Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España., Torres Díaz A; Servicio de Neurocirugía, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España., Suárez Balaguer J; Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España., Villabona Artero C; Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
Jazyk:	English; Spanish; Castilian
Zdroj:	Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion [Endocrinol Nutr] 2015 Feb; Vol. 62 (2), pp. 72-9. Date of Electronic Publication: 2014 Nov 28.
DOI:	10.1016/j.endonu.2014.10.004
Abstrakt:	Histiocytosis is characterized by proliferation of cells from the mononuclear phagocyte system, and may be divided into Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (including Erdheim-Chester disease [ECD]). While diabetes insipidus (DI) is the most common hypothalamic-pituitary consequence, anterior pituitary deficiencies are less known. This study analyzed the frequency and progression of pituitary hormone deficiencies and the radiographic findings in 9 patients (7 with LCH and 2 with ECD) with hypothalamic-pituitary (HP) axis. Eighty-nine percent of patients had DI (62% at diagnosis), and 78% had one or more anterior pituitary deficiencies (71% at diagnosis). HP involvement is relatively common in patients diagnosed with histiocytosis and hormone deficiencies may be present at diagnosis or appear gradually during the course of disease. Regular monitoring of these patients is recommended. (Copyright © 2014 SEEN. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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