Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage-effect study.

Autor: Lizarraga I; Department of Biomedical Sciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis., Castillo-Alcala F; Department of Biomedical Sciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis., Varner KM; Department of Biomedical Sciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis., Robinson LS; Department of Biomedical Sciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.
Jazyk: angličtina
Zdroj: The Veterinary record [Vet Rec] 2015 Feb 21; Vol. 176 (8), pp. 202. Date of Electronic Publication: 2014 Nov 27.
DOI: 10.1136/vr.102569
Abstrakt: There is limited, useful, scientific information on detomidine in donkeys. This study compared the effects of intravenous saline, detomidine (10, 13.5, 17 and 20 μg/kg) and acepromazine (50 μg/kg) in donkeys by computing areas under the curve for 0-30, 30-60 and 60-120 minutes (AUC0-30, AUC30-60 and AUC60-120) for sedation scores, head heights and mechanical nociceptive thresholds (MNTs). For sedation scores, all detomidine treatments, except 10 μg/kg, increased AUC0-30 values compared with saline, and AUC0-30 values were larger for 17 μg/kg detomidine than for acepromazine. All head height AUC values were lower for detomidine than for saline (except AUC60-120 for 10 μg/kg detomidine) and acepromazine (except AUC0-30 for 10 and 20 μg/kg detomidine, and AUC60-120 for 10 μg/kg detomidine). For MNTs, all detomidine treatments increased AUC0-30 and AUC30-60 values compared with saline and acepromazine; AUC30-60 values were smaller for 10 μg/kg than for 17 and 20 μg/kg detomidine. MNT AUC60-120 values were larger for 20 μg/kg detomidine than for saline, 10 μg/kg detomidine and acepromazine. Detomidine induced sedation and antinociception, but only antinociception was dosage dependent. Selection of detomidine dosage for donkeys may depend on the required duration of sedation and/or degree of analgesia.
(British Veterinary Association.)
Databáze: MEDLINE
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