| Autor: |
Skryma RN, Zaĭtsev LM, Degtiar' VE, Kalashnikova LE, Kvita GI |
| Jazyk: |
ruština |
| Zdroj: |
Neirofiziologiia = Neurophysiology [Neirofiziologiia] 1989; Vol. 21 (1), pp. 24-31. |
| Abstrakt: |
The effect of LTC4, a synthetic leukotriene, and of BW 755C, a blocker of its biosynthesis on the functioning of Ca-channels in the membrane of snail neurons and on the contractile activity of rat uterus muscles in late terms of pregnancy was studied by means of intracellular dialysis and spontaneous contractility recording techniques. It was found that the 10(-7) mol/l of LTC4 stimulated the contractile function of the rat uterus and activated effectively the Ca-conductance in the somatic membrane of the nervous cell. The action of BW 755C was similar to that of leukotriene on Ca-conductance; in addition BW 755C produced transient activation of contractions of the rat uterus followed by a complete suppression of smooth muscle contractions. Possible mechanisms of the effects described were discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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