| Autor: |
Varner CT; The Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute , Troy, New York 12180, United States., Rosen T, Martin JT, Kane RS |
| Jazyk: |
angličtina |
| Zdroj: |
Biomacromolecules [Biomacromolecules] 2015 Jan 12; Vol. 16 (1), pp. 43-55. Date of Electronic Publication: 2014 Nov 26. |
| DOI: |
10.1021/bm5014469 |
| Abstrakt: |
Polyvalent interactions, where multiple ligands and receptors interact simultaneously, are ubiquitous in nature. Synthetic polyvalent molecules, therefore, have the ability to affect biological processes ranging from protein-ligand binding to cellular signaling. In this review, we discuss recent advances in polyvalent scaffold design and applications. First, we will describe recent developments in the engineering of polyvalent scaffolds based on biomolecules and novel materials. Then, we will illustrate how polyvalent molecules are finding applications as toxin and pathogen inhibitors, targeting molecules, immune response modulators, and cellular effectors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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