Recruitment and retention of pregnant women into clinical research trials: an overview of challenges, facilitators, and best practices.

Autor:	Frew PM; Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases Emory Rollins School of Public Health, Department of Behavioral Sciences and Health Education, Emory University, Atlanta, Georgia., Saint-Victor DS; Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases., Isaacs MB; NIH Office of Research on Women's Health., Kim S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Swamy GK; Duke University, Durham, North Carolina., Sheffield JS; University of Texas Southwestern Medical Center, Dallas., Edwards KM; Vanderbilt University Medical Center, Nashville, Tennessee., Villafana T; MedImmune, Gaithersburg, Maryland., Kamagate O; Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases., Ault K; Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2014 Dec 15; Vol. 59 Suppl 7, pp. S400-7.
DOI:	10.1093/cid/ciu726
Abstrakt:	Pregnant women are a vulnerable group who are needed in clinical research studies to advance prevention and treatment options for this population. Yet, pregnant women remain underrepresented in clinical research. Through the lens of the socioecological model, we highlight reported barriers and facilitators to recruitment and retention of pregnant women in studies that sought their participation. We trace historical, policy-based reasons for the exclusion of pregnant women in clinical studies to present-day rationale for inclusion of this group. The findings highlight why it has been difficult to recruit and retain this population over time. A body of literature suggests that integrative sampling and recruitment methods that leverage the influence and reach of prenatal providers will overcome recruitment challenges. We argue that these strategies, in combination with building strong engagement with existing community-based organizations, will enable teams to more effectively promote and retain pregnant women in future longitudinal cohort studies. (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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