| Autor: |
Kitawi RC; 1 Center for Research in Therapeutic Sciences, Strathmore University , Nairobi, Kenya ., Nzomo T, Mwatelah RS, Aman R, Kimulwo MJ, Masankwa G, Lwembe RM, Okendo J, Ogutu B, Ochieng W |
| Jazyk: |
angličtina |
| Zdroj: |
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2015 Apr; Vol. 31 (4), pp. 452-5. Date of Electronic Publication: 2014 Dec 18. |
| DOI: |
10.1089/AID.2014.0306 |
| Abstrakt: |
There is a continuous need to genetically characterize the HIV strains in circulation in order to assess interventions and inform vaccine discovery. We partially sequenced the envelope C2V3 gene from a total of 59 Kenyan patients on highly active antiretroviral treatment (HAART) and determined HIV subtypes using both the JPHMM subtyping tool and the phylogenetic method. HIV-1 subtype A1 was the predominant strain in circulation, representing 65.5% and 74.5% of all isolates as determined by JPHMM and phylogenetic methods, respectively. Subtypes C and D were the next most prevalent pure strains at 9.1% each by both methods. JPHMM identified 9.1% of the isolates as recombinant. Four isolates had short sequences not covering the entire C2V3 region and were thus not subtyped. From this study, subtype A viruses are still the predominant HIV-1 strains in local circulation in Kenya. Constant surveillance is needed to update molecular trends under continuing HAART scale-up. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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