Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration.

Autor:	Willeit P; The Department of Public Health and Primary Care, University of Cambridge, UK Department of Neurology, Medical University Innsbruck, Austria., Thompson SG; The Department of Public Health and Primary Care, University of Cambridge, UK., Agewall S; Institute of Clinical Sciences, University of Oslo, and the Department of Cardiology, Oslo University Hospital Ullevål, Norway., Bergström G; Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Sweden., Bickel H; Department of Psychiatry and Psychotherapy, University Hospital of the Technische Universität München, Germany., Catapano AL; Department of Pharmacological Sciences, University of Milan, and IRCSS Multimedica Sesto S Giovanni, Milan, Italy., Chien KL; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan Department of Internal Medicine, National Taiwan University, Taipei, Taiwan., de Groot E; Academic Medical Centre, Cardiology and Thoracic Surgery, and Imagelabonline and Cardiovascular, Amsterdam, The Netherlands., Empana JP; INSERM, U970, Université Paris Descartes, France., Etgen T; Department of Neurology, Kliniken Südostbayern, Klinikum Traunstein, Germany., Franco OH; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands., Iglseder B; Department of Geriatric Medicine, Paracelsus Medical University, and the Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft GmbH, Christian-Doppler-Klinik, Salzburg, Austria., Johnsen SH; Department of Neurology and Neurophysiology, University Hospital of Northern Norway, and the Department of Clinical Medicine, University of Tromsø, Tromsø, Norway., Kavousi M; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands., Lind L; Department of Medicine, Uppsala University, Sweden., Liu J; Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, PR China., Mathiesen EB; Department of Neurology and Neurophysiology, University Hospital of Northern Norway, and the Department of Clinical Medicine, University of Tromsø, Tromsø, Norway., Norata GD; Department of Pharmacological Sciences, University of Milan, and the SISA Centre for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy., Olsen MH; Department of Endocrinology, Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, Denmark., Papagianni A; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration General Hospital, Greece., Poppert H; Department of Neurology, University Hospital of the Technische Universität München, Germany., Price JF; Centre for Population Health Sciences, University of Edinburgh, UK., Sacco RL; Department of Neurology, Miller School of Medicine, University of Miami, FL, USA., Yanez DN; Department of Biostatistics, University of Washington, Seattle, WA, USA., Zhao D; Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, PR China., Schminke U; Department of Neurology, Greifswald University Clinic, Germany., Bülbül A; Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, Germany., Polak JF; Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA., Sitzer M; Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, Germany Department of Neurology, Klinikum Herford, Germany., Hofman A; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA., Grigore L; Department of Pharmacological Sciences, University of Milan, and the SISA Centre for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy., Dörr M; Department B for Internal Medicine, University Medicine Greifswald, and the German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Germany., Su TC; Department of Internal Medicine, National Taiwan University, Taipei, Taiwan., Ducimetière P; University Paris Sud-XI, Kremlin-Bicêtre, France., Xie W; Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, PR China., Ronkainen K; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Kiechl S; Department of Neurology, Medical University Innsbruck, Austria., Rundek T; Department of Neurology, Miller School of Medicine, University of Miami, FL, USA., Robertson C; Centre for Population Health Sciences, University of Edinburgh, UK., Fagerberg B; Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Sweden., Bokemark L; Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Sweden., Steinmetz H; Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, Germany., Ikram MA; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands., Völzke H; Institute for Community Medicine, SHIP/Clinical-Epidemiological Research, Greifswald, Germany., Lin HJ; Department of Internal Medicine, National Taiwan University, Taipei, Taiwan Health Management Centre, National Taiwan University Hospital, Taipei, Taiwan., Plichart M; INSERM, U970, Université Paris Descartes, France Gerontology Department, Broca Hospital, Paris, France., Tuomainen TP; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Desvarieux M; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA, and the École des Hautes Études en Santé Publique, and INSERM U738, Paris, France., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, UK., Schmidt C; Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Sweden., Kauhanen J; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Willeit J; Department of Neurology, Medical University Innsbruck, Austria., Lorenz MW; Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, Germany., Sander D; Department of Neurology, Benedictus Krankenhaus Tutzing and Feldafing, Tutzing, Germany and Technische Universität München, Germany D.Sander@mac.com.
Jazyk:	angličtina
Zdroj:	European journal of preventive cardiology [Eur J Prev Cardiol] 2016 Jan; Vol. 23 (2), pp. 194-205. Date of Electronic Publication: 2014 Nov 21.
DOI:	10.1177/2047487314560664
Abstrakt:	Background: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Methods: Information on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. Results: Mean baseline CCA-IMT amounted to 0.74 mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082 mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072 mm for fibrinogen (p < 0.001); and 0.0025 mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015). Conclusion: Inflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis. (© The European Society of Cardiology 2014.)
Databáze:	MEDLINE
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