Neopterin: a potential biomarker for delirium in elderly patients.
| Autor: | Egberts A; Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Wijnbeld EH, Fekkes D, van der Ploeg MA, Ziere G, Hooijkaas H, van der Cammen TJ, Mattace-Raso FU |
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| Jazyk: | angličtina |
| Zdroj: | Dementia and geriatric cognitive disorders [Dement Geriatr Cogn Disord] 2015; Vol. 39 (1-2), pp. 116-24. Date of Electronic Publication: 2014 Nov 19. |
| DOI: | 10.1159/000366410 |
| Abstrakt: | Background/aims: The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admitted elderly patients with and without a delirium. Methods: Plasma/serum levels of neopterin, IL-6 and IGF-1 were determined in patients aged ≥65 years admitted to the wards of Internal Medicine and Geriatrics. Differences in biomarker levels between patients with and without a delirium were investigated by the analysis of variance in models adjusted for age, gender, comorbidities and eGFR (when appropriate). Results: Eighty-six patients were included; 23 of them with a delirium. In adjusted models, higher mean levels of neopterin (70.5 vs. 45.9 nmol/l, p = 0.009) and IL-6 (43.1 vs. 18.5 pg/ml, p = 0.034) and lower mean levels of IGF-1 (6.3 vs. 9.3 nmol/l, p = 0.007) were found in patients with a delirium compared to those without. Conclusions: The findings of this study suggest that neopterin might be a potential biomarker for delirium which, through oxidative stress and activation of the immune system, may play a role in the pathophysiology of delirium. (© 2014 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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