| Autor: |
Brown AL; Department of Virology, Wellcome Biotechnology Ltd., Beckenham, Kent, U.K., Campbell RO, Clarke BE |
| Jazyk: |
angličtina |
| Zdroj: |
Gene [Gene] 1989 Feb 20; Vol. 75 (2), pp. 225-33. |
| DOI: |
10.1016/0378-1119(89)90268-0 |
| Abstrakt: |
The nucleotide sequence coding for the structural proteins and nonstructural protein P2A has been determined for a foot-and-mouth disease virus (FMDV) isolated in Africa. This virus, serotypically designated SAT3 (South African Territories type 3), shows about 60% homology at the nucleotide level to prototype viruses from the O, A and C serotypes of FMDV. The highest region of variability was shown in structural protein VP1, presumably a consequence of its position on the surface of the virus and its exposure to selection pressure by neutralising antibody. Within this region amino acids (aa) 141-160, which have been shown to represent an immunodominant region in other FMDV serotypes, showed hypervariability as well as the insertion of 5 or 9 additional aa relative to the O1 and C1 serotypes, respectively. In contrast, the sequence of nonstructural protein P2A was completely conserved indicating a probable important role in virus replication. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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