| Autor: |
Cheong JY; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea., Shin HD; Department of Life Science, Sogang University, Seoul, Korea., Cho SW; Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea., Kim YJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of Korean medical science [J Korean Med Sci] 2014 Nov; Vol. 29 (11), pp. 1523-7. Date of Electronic Publication: 2014 Nov 04. |
| DOI: |
10.3346/jkms.2014.29.11.1523 |
| Abstrakt: |
MicroRNA polymorphisms may be associated with carcinogenesis or immunopathogenesis of infection. We evaluated whether the mircoRNA-604 (miR-604) polymorphism can affect the persistence of hepatitis B virus (HBV) infection, and the development to hepatocellular carcinoma (HCC) in patients with chronic HBV infection. A total of 1,439 subjects, who have either past or present HBV infection, were enrolled and divided into four groups (spontaneous recovery, chronic HBV carrier without cirrhosis, liver cirrhosis and HCC). We genotyped the precursor miR-604 genome region polymorphism. The CC genotype of miR-604 rs2368392 was most frequently observed and T allele frequency was 0.326 in all study subjects. The HBV persistence after infection was higher in those subjects with miR-604 T allele (P=0.05 in a co-dominant and dominant model), which implied that the patients with miR-604 T allele may have a higher risk for HBV chronicity. In contrast, there was a higher rate of the miR-604 T allele in the chronic carrier without HCC patients, compared to those of the HCC patients (P=0.03 in a co-dominant model, P=0.02 in a recessive model). The T allele at miR-604 rs2368392 may be a risk allele for the chronicity of HBV infection, but may be a protective allele for the progression to HCC in chronic HBV carriers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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