| Autor: |
Misic MM; College for Specialized Studies in Belgrade, Cara Dusana 254, 11080, Zemun, Serbia., Jakovljevic VL, Bugarcic ZD, Zivkovic VI, Srejovic IM, Barudzic NS, Djuric DM, Novokmet SS |
| Jazyk: |
angličtina |
| Zdroj: |
Cardiovascular toxicology [Cardiovasc Toxicol] 2015 Jul; Vol. 15 (3), pp. 261-8. |
| DOI: |
10.1007/s12012-014-9293-8 |
| Abstrakt: |
We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt((II))DACHCl2), dichloro-(ethylenediamine)platinum(II) (Pt((II))ENCl2), tetrachloro-(1,2-diaminocyclohexane)platinum(IV) (Pt((IV))DACHCl4) and tetrachloro-(ethylenediamine)platinum(IV) (Pt((II))ENCl4) were perfused at increasing concentrations of 10(-8), 10(-7), 10(-6), 10(-5) and 10(-4) M during 30 min. In this paper, we report that cisplatin-induced dose-dependent effects on cardiac contractility and coronary flow both manifested as decrease in cardiac contractile force (dP/dt)max, heart rate and significant reduction in CF. Pt((II))ENCl2, Pt((IV))ENCl2 and Pt((IV))DACHCl4 did induce dose-dependent response only in case of CF. Our results could be also important for better understanding dose-dependent side effects of potential metal-based anticancer drugs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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