| Autor: |
Trabelsi AB; Department of Gastroenterology, Sahloul Sousse, Tunisia., Hamami E; Department of Gastroenterology, Sahloul Sousse, Tunisia., Souguir A; Department of Gastroenterology, Sahloul Sousse, Tunisia., Ksiaa M; Department of Gastroenterology, Sahloul Sousse, Tunisia., Ajmi S; Department of Gastroenterology, Sahloul Sousse, Tunisia., Jmaa A; Department of Gastroenterology, Sahloul Sousse, Tunisia. |
| Jazyk: |
angličtina |
| Zdroj: |
The Pan African medical journal [Pan Afr Med J] 2014 Mar 07; Vol. 17, pp. 174. Date of Electronic Publication: 2014 Mar 07 (Print Publication: 2014). |
| DOI: |
10.11604/pamj.2014.17.174.3018 |
| Abstrakt: |
In recent years, the hepatotoxic potential of thiopurines, in particular 6-thioguanine (6-TG) has been discussed in literature. However, cirrhosis was exceptionally reported. We report the case of a 56-year-old woman with ileocaecal Crohn's disease treated with azathioprine. After taking azathioprine (2 mg/kg daily) for four years, she underwent surgical treatment for acute intestinal obstruction. In peroperative, we noticed a cirrhotic liver. A surgical biopsy was performed and the diagnosis of cirrhosis was confirmed. Autoimmune and viral liver diseases were ruled out by laboratory parameters. Therefore, Azathioprine is believed to be the causative actor for inducing liver cirrhosis. Thus, treating inflammatory bowel disease effectively while trying to limit iatrogenic disease is a continuous struggle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
