| Autor: |
Cicatiello AG; Department of Molecular Medicine and Medical Biotechnology, Federico II University Medical School, Naples, Italy., Iula DV, Pagliuca C, Pastore G, Pagliarulo C, Catania MR, Catania MR, Colicchio R, Picardi M, Raia V, Salvatore P |
| Jazyk: |
angličtina |
| Zdroj: |
The new microbiologica [New Microbiol] 2014 Oct; Vol. 37 (4), pp. 567-71. Date of Electronic Publication: 2014 Oct 01. |
| Abstrakt: |
Cystic fibrosis is a genetic disorder associated with a polymicrobial lung infection where classical pathogens and newly identified bacteria may interact. Inquilinus limosus is an a-proteobacterium recently isolated in the airways of cystic fibrosis patient. We report the first case in Italy of I.limosus isolation from the sputum sample of a cystic fibrosis patient. The patient is a 20-years-old man with cystic fibrosis, regularly attending the Regional Care Center for Cystic Fibrosis at the Federico II University Hospital of Naples. Microbiological culture methods detected a mu- coid gram negative bacillus in the patient's sputum sample. The isolate exhibited a distinct antimicrobial suscep- tibility profile with a high MIC for several drugs. The MALDI-TOF mass spectrometry analysis indicated the bac- terium isolated as I. limosus, confirmed by 16s rDNA sequence analysis. The described clinical case demonstrates how the bacterial biodiversity in the airways of cystic fibrosis patients is still underestimated. Cystic fibrosis lung represents an ecological niche suitable for growth of a wide variety of unusual bacteria not commonly associated with human diseases, such as I. limosus. Therefore further studies are needed to evaluate the epidemiology and clinical implications of I. limosus in the physiopathology of cystic fibrosis lung infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
