| Autor: |
Zhang P; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA ; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Kling RE; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Ravuri SK; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Kokai LE; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Rubin JP; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA ; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA ; McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA., Chai JK; Department of Burns and Plastic Surgery, First Hospital Affiliated to General Hospital of PLA, Beijing, China., Marra KG; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA ; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA ; McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA. |
| Abstrakt: |
Alopecia is an exceedingly prevalent problem effecting men and women of all ages. The standard of care for alopecia involves either transplanting existing hair follicles to bald areas or attempting to stimulate existing follicles with topical and/or oral medication. Yet, these treatment options are fraught with problems of cost, side effects, and, most importantly, inadequate long-term hair coverage. Innovative cell-based therapies have focused on the dermal papilla cell as a way to grow new hair in previously bald areas. However, despite this attention, many obstacles exist, including retention of dermal papilla inducing ability and maintenance of dermal papilla productivity after several passages of culture. The use of adipocyte lineage cells, including adipose-derived stem cells, has shown promise as a cell-based solution to regulate hair regeneration and may help in maintaining or increasing dermal papilla cells inducing hair ability. In this review, we highlight recent advances in the understanding of the cellular contribution and regulation of dermal papilla cells and summarize adipocyte lineage cells in hair regeneration. |
