Trienamine-mediated asymmetric [4+2]-cycloaddition of α,β-unsaturated ester surrogates applying 4-nitro-5-styrylisoxazoles.

Autor: Li Y; Center for Catalysis, Department of Chemistry, Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark. kaj@chem.au.dk., López-Delgado FJ, Jørgensen DK, Nielsen RP, Jiang H, Jørgensen KA
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2014 Dec 25; Vol. 50 (99), pp. 15689-91. Date of Electronic Publication: 2014 Nov 06.
DOI: 10.1039/c4cc08171d
Abstrakt: Highly enantioselective organocatalytic [4+2]-cycloaddition of in situ generated trienamines with 4-nitro-5-styrylisoxazoles as α,β-unsaturated ester surrogates is presented. The synthetic utility of this strategy is demonstrated by transforming the formed cycloadducts into optically active carboxylates.
Databáze: MEDLINE