Bone and vitamin D status in patients with anorexia nervosa.
| Autor: | Eriksen SA; Department of Clinical Medicine, Aalborg University, Room 320, Sdr. Skovvej 15, 9000 Aalborg, Denmark. stine.eriksen@rn.dk., Prietzel H, Ibsen JR, Lauritsen MB, Vestergaard P, Telléus GK |
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| Jazyk: | angličtina |
| Zdroj: | Danish medical journal [Dan Med J] 2014 Nov; Vol. 61 (11), pp. A4940. |
| Abstrakt: | Introduction: The aim of the present study was to investigate bone status and biological mechanisms involved in the negative impact of anorexia nervosa (AN) on osteogenesis. Methods: A total of 30 AN patients from Aalborg University Hospital who underwent bone scans were included in a cross-sectional study. Biochemical data, bone scans (dual-energy X-ray absorptiometry (DXA)) as well as general health and medical information had been collected during the 2009-2011 period and stored via local and national clinical databases in Denmark, and from these databases we identified all patients with an AN diagnosis who underwent bone scans. Results: AN patients had a mean Z-score of -1.5 to -1.6 in lumbar spine and total hip, respectively. The hip Z-score decreased with duration of disease, and a positive correlation was seen between serum 25-hydroxy-vitamin D level and spine Z-score but not hip Z-score. Bone mineral density did not seem to change with time since diagnosis. Additionally, a negative correlation between serum 25-hydroxy-vitamin D levels and serum total alkaline phosphatase levels was found. A serum 25-hydroxy-vitamin D level below 50 nmol/l was associated with increased alkaline phosphatase levels. Conclusion: Rather than clinical measures including BMI and biochemical measures disease duration was the main predictor of bone status. This implies that long-term disease should be a main factor in selecting patients for referral to DXA. Moreover, results from this study indicate normal osteoblastic response to malnutrition. Funding: not relevant. Trial Registration: The present study was not registered due to its register-based design. However, the study was approved by the Danish Data Protection Agency. |
| Databáze: | MEDLINE |
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