Increase in oxygen consumption after albuterol inhalation in ventilated infants and children.
| Autor: | Ross PA; Division of Critical Care, Children's Hospital Los Angeles, University of Southern California School of Medicine, Los Angeles, CA., Newth CJ, Hugen CA, Maher JK, Deakers TW |
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| Jazyk: | angličtina |
| Zdroj: | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2014 Nov; Vol. 15 (9), pp. e389-92. |
| DOI: | 10.1097/PCC.0000000000000279 |
| Abstrakt: | Objective: To determine if inhaled albuterol (salbutamol) increases oxygen consumption (V'O2) in children and, if so, the duration of this effect. Design: Oxygen consumption was measured by indirect calorimetry using the Argon dilution technique with a respiratory mass spectrometer. After measurement of baseline values, albuterol was administered and subsequent measurements were performed at 10 minutes, 1 hour, 2 hours, 3 hours, and 4 hours. Setting: Multidisciplinary PICU in a university teaching hospital. Patients: Eleven intubated infants and children (five girls, six boys) with a mean age of 20 months (range, 1 mo to 8 yr) and a mean weight of 10.7 kg (range, 3.1-23 kg) who required therapeutic albuterol inhalations. Intervention: Nine hundred micrograms of albuterol (10 puffs) was administered by a metered-dose inhaler into a spacer through the inspiratory arm of the ventilator circuit near to the patient, during 10 mechanically assisted breaths. Measurements and Main Results: All children showed an increase in V'O2 within 10 minutes (mean increase 48.6%). The increased V'O2 was still elevated (42.3% above baseline) at 1 hour, but 3 hours after albuterol inhalation, the V'O2 was back to baseline in all patients. Heart rate increased significantly at 10 minutes, 1 hour, and 2 hours after inhalation. Conclusion: There is a large increase in V'O2 after albuterol inhalation. This effect lasts up to 3 hours. |
| Databáze: | MEDLINE |
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