| Autor: |
Brinckerhoff CE; Department of Medicine, Dartmouth Medical School, Hanover, NH 03756., Mitchell TI, Karmilowicz MJ, Kluve-Beckerman B, Benson MD |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1989 Feb 03; Vol. 243 (4891), pp. 655-7. |
| DOI: |
10.1126/science.2536953 |
| Abstrakt: |
Two autocrine proteins of 14 and 12 kilodaltons that induce the synthesis of rabbit fibroblast collagenase were identified. The proteins were purified from serum-free culture medium taken from rabbit synovial fibroblasts stimulated with phorbol myristate acetate. The amino-terminal sequences of the 14- and 12-kilodalton species were approximately 60 to 80 percent homologous with serum amyloid A and beta 2 microglobulin, respectively. The polyacrylamide gel-eluted proteins retained the ability to induce collagenase synthesis in rabbit and human fibroblasts. These autocrine proteins may provide a means to modulate collagenase synthesis in normal remodeling as well as in inflammation and disease states. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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