Familial cardiomyopathy in Norwegian Forest cats.

Autor:	März I; Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, UK., Wilkie LJ; Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, UK., Harrington N; Department of Pathology and Pathogen Biology, The Royal Veterinary College, Hatfield, UK., Payne JR; Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, UK., Muzzi RA; Department of Veterinary Medicine, Federal University of Lavras, Minas Gerais, Brazil., Häggström J; Department of Clinical Sciences, Swedish University of Agricultural Science, Uppsala, Sweden., Smith K; Department of Pathology and Pathogen Biology, The Royal Veterinary College, Hatfield, UK., Luis Fuentes V; Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, UK vluisfuentes@rvc.ac.uk.
Jazyk:	angličtina
Zdroj:	Journal of feline medicine and surgery [J Feline Med Surg] 2015 Aug; Vol. 17 (8), pp. 681-91. Date of Electronic Publication: 2014 Oct 30.
DOI:	10.1177/1098612X14553686
Abstrakt:	Norwegian Forest cats (NFCs) are often listed as a breed predisposed to cardiomyopathy, but the characteristics of cardiomyopathy in this breed have not been described. The aim of this preliminary study was to report the features of NFC cardiomyopathy based on prospective echocardiographic screening of affected family groups; necropsy findings; and open-source breed screening databases. Prospective examination of 53 NFCs revealed no murmur or left ventricular (LV) outflow tract obstruction in any screened cat, though mild LV hypertrophy (defined as diastolic LV wall thickness ≥5.5mm) was present in 13/53 cats (25%). Gross pathology results and histopathological sections were analysed in eight NFCs, six of which had died of a cardiac cause. Myocyte hypertrophy, myofibre disarray and interstitial fibrosis typical of hypertrophic cardiomyopathy were present in 7/8 cats, but endomyocardial fibrosis suggestive of restrictive cardiomyopathy was also present in the same cats. Pedigree data analysis from 871 NFCs was supportive of a familial cardiomyopathy in this breed. (© ISFM and AAFP 2014.)
Databáze:	MEDLINE
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