| Autor: |
Castagna A; Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy., Channavajjhala SK, Pizzolo F, Olivieri O |
| Jazyk: |
angličtina |
| Zdroj: |
Advances in experimental medicine and biology [Adv Exp Med Biol] 2015; Vol. 845, pp. 103-20. |
| DOI: |
10.1007/978-94-017-9523-4_11 |
| Abstrakt: |
Human urine represents a good source for proteomic research for clinically related studies as it can be collected and processed easily and can give information about kidney-related mechanisms. Little is known about the urinary proteomic changes resulting from physiological (normal), pathological, or environmental variations, and there are few reports on hormone-related modifications of urine proteome. In our study, we highlighted the variations of urinary proteins associated with menstrual cycle or estro-progestin pill in females. We also described an association between some urinary proteins and the renin-angiotensin-aldosterone system, which might help to improve the understanding of physiological and pathological processes when a gender-specific pattern such as the menopause-related hypertension or eclampsia is evident. We therefore support the usefulness of urinary proteomics as a valuable tool for clinically related study as it can provide information on candidate biomarkers which, in turn, need to be confirmed by multiple approaches before the use in a clinical setting. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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