Human papillomavirus virus (HPV) genotype- and age-specific analyses of external genital lesions among men in the HPV Infection in Men (HIM) Study.

Autor:	Ingles DJ; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Pierce Campbell CM; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Messina JA; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Stoler MH; University of Virginia School of Medicine, Charlottesville., Lin HY; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Fulp WJ; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Abrahamsen M; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Sirak BA; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., O'Keefe MT; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Papenfuss M; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida University of Virginia School of Medicine, Charlottesville University of São Paulo School of Medicine, Brazil Instituto Nacional de Salud Pública, Cuernavaca, Mexico., Gage C; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida., Carvalho da Silva R; University of São Paulo School of Medicine, Brazil., Gonzalez Sosa R; Instituto Nacional de Salud Pública, Cuernavaca, Mexico., Rojas Juarez O; Instituto Nacional de Salud Pública, Cuernavaca, Mexico., Villa LL; University of São Paulo School of Medicine, Brazil., Lazcano Ponce E; Instituto Nacional de Salud Pública, Cuernavaca, Mexico., Giuliano AR; Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2015 Apr 01; Vol. 211 (7), pp. 1060-7. Date of Electronic Publication: 2014 Oct 24.
DOI:	10.1093/infdis/jiu587
Abstrakt:	Background: Human papillomavirus (HPV) causes external genital lesions (EGLs) in men, including condyloma and penile intraepithelial neoplasia (PeIN). We sought to determine the incidence of pathologically confirmed EGLs, by lesion type, among men in different age groups and to evaluate the HPV types that were associated with EGL development. Methods: HPV Infection in Men (HIM) study participants who contributed ≥2 visits from 2009-2013 were included in the biopsy cohort. Genotyping by an HPV line-probe assay was performed on all pathologically confirmed EGLs. Age-specific analyses were conducted for incident EGLs, with Kaplan-Meier estimation of cumulative incidence. Results: This biopsy cohort included 2754 men (median follow-up duration, 12.4 months [interquartile range, 6.9-19.2 months]). EGLs (n = 377) were pathologically confirmed in 228 men, 198 of whom had incident EGLs. The cumulative incidence of any EGL was highest among men <45 years old and, for condyloma, decreased significantly over time with age. The genotype-specific incidence of EGL varied by pathological diagnoses, with high- and low-risk genotypes found in 15.6% and 73.2% of EGLs, respectively. Condyloma primarily contained HPV 6 or 11. While PeIN lesions primarily contained HPV 16, 1 PeIN III lesion was positive for HPV 6 only. Conclusion: Low- and high-risk HPV genotypes contribute to the EGL burden. Men remain susceptible to HPV-related EGLs throughout the life span, making it necessary to ensure the longevity of immune protection against the most common causative HPV genotypes. (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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