Recombination and replication.
| Autor: | Syeda AH; Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom., Hawkins M; Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom., McGlynn P; Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2014 Oct 23; Vol. 6 (11), pp. a016550. Date of Electronic Publication: 2014 Oct 23. |
| DOI: | 10.1101/cshperspect.a016550 |
| Abstrakt: | The links between recombination and replication have been appreciated for decades and it is now generally accepted that these two fundamental aspects of DNA metabolism are inseparable: Homologous recombination is essential for completion of DNA replication and vice versa. This review focuses on the roles that recombination enzymes play in underpinning genome duplication, aiding replication fork movement in the face of the many replisome barriers that challenge genome stability. These links have many conserved features across all domains of life, reflecting the conserved nature of the substrate for these reactions, DNA. (Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| Databáze: | MEDLINE |
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