Hypertrophic olivary degeneration and holmes' tremor secondary to bleeding of cavernous malformation in the midbrain.

Autor:	Menéndez DF; Division of Functional Neurosurgery of the Institute of Psychiatry of the Hospital das Clinicas of the University of São Paulo., Cury RG; Abnormal Movements Unit of the Hospital das Clinicas of the University of São Paulo., Barbosa ER; Abnormal Movements Unit of the Hospital das Clinicas of the University of São Paulo., Teixeira MJ; Discipline of Neurosurgery of the São Paulo University Medical School., Fonoff ET; Discipline of Neurosurgery of the São Paulo University Medical School.
Jazyk:	angličtina
Zdroj:	Tremor and other hyperkinetic movements (New York, N.Y.) [Tremor Other Hyperkinet Mov (N Y)] 2014 Oct 08; Vol. 4, pp. 264. Date of Electronic Publication: 2014 Oct 08 (Print Publication: 2014).
DOI:	10.7916/D8PG1PXT
Abstrakt:	Background: Hypertrophic olivary degeneration (HOD) is a rare phenomenon, probably related to transsynaptic degeneration of the inferior olivary nucleus. It usually occurs as a response to primary injury of dento-rubro-olivary pathways. Case Report: A young man developed Holmes' tremor 7 months after a cavernous malformation bleed in the midbrain. Typical findings of HOD were observed in the magnetic resonance images: bilateral and asymmetric hypertrophy of the olivary nucleus with slight hypersignal in T2-weighted images. Because of the striking disability related to drug-resistant tremor, the patient underwent stereotactic thalamotomy (nucleus ventralis intermedius of the thalamus/zona incerta) with pronounced functional improvement over time. Discussion: Disruption of circuits in the Guillain-Mollaret triangle classically results in palatal myoclonus, however midbrain (Holmes') tremor can also occur, as we now describe.
Databáze:	MEDLINE
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