Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography?
| Autor: | Moussavi F; Department of Pediatric Hematology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghasabeh MA; Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital, Keshavarz Boulevard, Tehran University of Medical Sciences, Tehran, Iran., Roodpeyma S; Pediatric cardiology division, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Alavi S; Department of Pediatric Hematology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shakiba M; Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital, Keshavarz Boulevard, Tehran University of Medical Sciences, Tehran, Iran., Gheiratmand R; Department of Pediatric Hematology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Omidghaemi M; Department of Pediatric Hematology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Blood research [Blood Res] 2014 Sep; Vol. 49 (3), pp. 182-6. Date of Electronic Publication: 2014 Sep 25. |
| DOI: | 10.5045/br.2014.49.3.182 |
| Abstrakt: | Background: Heart failure resulting from myocardial iron deposition is the most important cause of death in β-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level serve as diagnostic methods for detecting myocardial iron overload. In this study, we aimed to evaluate the relationship between the above-mentioned methods. Methods: T2*MRI and echocardiographic measurement of left ventricular (LV) systolic and diastolic function were performed in 63 patients. Serum ferritin level was measured. The relationships between all assessments were evaluated. Results: There were 40 women and 23 men with a mean age of 23.7±5.1 years (range, 15-35 years). There was no statistically significant correlation between serum ferritin level and LV systolic and diastolic function (P=0.994 and P=0.475, respectively). T2*MRI results had a significant correlation with ferritin level; 63.6% of patients with serum ferritin level >2,000 ng/mL had abnormal cardiac MRI, while none of the patients with ferritin level <1,000 ng/mL had abnormal cardiac MRI (P=0.001). There was no significant correlation between MRI findings and LV systolic function (P=1.00). However, we detected a significant difference between LV diastolic function and cardiac siderosis (P=0.03). Conclusion: MRI findings are a good predictor of future cardiac dysfunction, even in asymptomatic TM patients; however, diastolic dysfunction may happen prior to cardiac siderosis in some patients, and echocardiography is able to diagnose this diastolic dysfunction while T2*MRI shows normal findings. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|