[Protective role of the G allele of the polymorphism in the Interleukin 10 gene (-1082G/A) against the development of preeclampsia].

Autor:	Pissetti CW; Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil., Bianco TM; Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil., Tanaka SC; Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil., Nascentes GA; Disciplina de Microbiologia e Imunologia, Instituto Federal do Triângulo Mineiro, Uberaba, MG, Brasil., Grecco RL; Disciplina de Genética, Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil., da Silva SR; Disciplina Enfermagem em Ginecologia e Obstetrícia, Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil., Balarin MA; Disciplina de Genética, Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
Jazyk:	portugalština
Zdroj:	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2014 Oct; Vol. 36 (10), pp. 456-60. Date of Electronic Publication: 2014 Oct 03.
DOI:	10.1590/so100-720320140005075
Abstrakt:	Purpose: To identify the frequency of polymorphism in the IL-10 gene, rs1800896 (-1082 A/G), in women with preeclampsia (PE) and in women in a control group and to associate the presence of this polymorphism with protection against the development of PE. Methods: This was a case-control study conducted on 54 women with PE, classified according to the criteria of the National High Blood Pressure Education Program, and on 172 control women with at least two healthy pregnancies. The proposed polymorphism was studied by the technique of real time polymerase chain reaction (qPCR), with hydrolysis probes. Statistical analysis was performed using the χ2 test. Odds ratio and confidence interval of 95% were used to measure the strength of association between the studied polymorphism and the development of PE. Results: Statistically increased frequency of the AG genotype was observed among control women (85 versus 15% in women with PE). The G allele was significantly more frequent among control women than PE women (χ2 test, p = 0.01). The odds ratio for carriers of the G allele was 2.13, indicating a lower risk of developing PE compared to non-carriers. Conclusions: Thus, an association is suggested to occur between the presence of the G allele of the polymorphism in the IL-10 rs1800896 (-1082 A/G) gene and protection against the development of PE. More studies investigating the contribution of these variations and the mechanisms by which they affect the risk of developing PE still need to be undertaken.
Databáze:	MEDLINE
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