Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma.

Autor: Navarria P; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy. Electronic address: piera.navarria@cancercenter.humanitas.it., Reggiori G; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Pessina F; Neurosurgical Oncology Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Ascolese AM; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Tomatis S; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Mancosu P; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Lobefalo F; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Clerici E; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Lopci E; Nuclear Medicine Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Bizzi A; Neuroradiology Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Grimaldi M; Neuroradiology Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Chiti A; Nuclear Medicine Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Simonelli M; Oncology and Hematology Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Santoro A; Oncology and Hematology Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Bello L; Neurosurgical Oncology Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy., Scorsetti M; Radiotherapy and Radiosurgery Department, Istituto Clinico Humanitas Cancer Center, Milan, Italy.
Jazyk: angličtina
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2014 Sep; Vol. 112 (3), pp. 425-9. Date of Electronic Publication: 2014 Oct 09.
DOI: 10.1016/j.radonc.2014.09.004
Abstrakt: Purpose: To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning.
Material and Methods: Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10mm margin to FLAIRMRI area, CTV2 by adding a 20mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively.
Results: The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area.
Conclusions: Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.
(Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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