A quantitative analysis of mast cells in inflammatory periapical and gingival lesions.

Autor:	Sheethal HS; Senior Lecturer, Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India, e-mail: sheethalhs6@gmail.com., Uma K; Professor and Head, Department of Oral and Maxillofacial Pathology, KLE Dental College and Hospital, Bengaluru, Karnataka, India., Rao K; Professor and Head, Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India., Priya NS; Reader, Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India., Umadevi HS; Reader, Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India., Smitha T; Reader, Department of Oral and Maxillofacial Pathology, VS Dental College, Bengaluru, Karnataka, India.
Jazyk:	angličtina
Zdroj:	The journal of contemporary dental practice [J Contemp Dent Pract] 2014 May 01; Vol. 15 (3), pp. 300-5. Date of Electronic Publication: 2014 May 01.
DOI:	10.5005/jp-journals-10024-1532
Abstrakt:	Aim: The aim of the study was to quantify the presence of mast cells in various inflammatory lesions like periapical granuloma, periapical cyst, inflammatory gingival hyperplasia and pyogenic granuloma. Mast cell degranulation and association with lymphocytes were also recorded in an attempt to understand the role of mast cells in the pathogenesis of these inflammatory lesions. Materials and Methods: The quantification of mast cells was done on toluidine blue stained sections of all the four groups of lesions, using the image analyzer software, Image-Pro-Express (Media Cybernetics, USA). Results: An increased number of mast cells in various inflammatory lesions with a significant difference between the four groups were noted. Mast cell number tended to be greater in the lesions present in the anterior region of the mouth than in the posterior region of the oral cavity. The mean mast cell number decreased with the increasing age which was directly correlated with the age of the patients. Mast cell site, distribution, degranulation and its association with fibroblasts, lymphocytes and blood vessels were noted. Conclusion: The location of mast cells in different areas, their association with lymphocytes, fibroblasts, endothelial cells, and the phenomenon of degranulation helps to appreciate the release of various mediators and multiple interactions among these cells, leading to increased vascular permeability, angiogenic response, collagen synthesis, regulation of inflammation, bone resorption, and extracellular matrix destruction, thus contributing to the pathogenesis of these inflammatory lesions.
Databáze:	MEDLINE
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