Frequency of p190 and p210 BCR-ABL rearrangements and survival in Brazilian adult patients with acute lymphoblastic leukemia.

Autor: de França Azevedo I; Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil. Electronic address: ilanafranca87@gmail.com., da Silva Júnior RM; Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil., de Vasconcelos AV; Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil., das Neves WB; Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil., de Barros Correia Melo FC; Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil., Melo RA; Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil.
Jazyk: angličtina
Zdroj: Revista brasileira de hematologia e hemoterapia [Rev Bras Hematol Hemoter] 2014 Sep-Oct; Vol. 36 (5), pp. 351-5. Date of Electronic Publication: 2014 Jul 18.
DOI: 10.1016/j.bjhh.2014.07.016
Abstrakt: Objective: This study investigated the occurrence of the p190 and p210 breakpoint cluster region-Abelson (BCR-ABL) rearrangements in adults with acute lymphoblastic leukemia and possible associations with clinical and laboratory characteristics and survival.
Methods: Forty-one over 18-year-old patients with acute lymphoblastic leukemia of both genders followed-up between January 2008 and May 2012 were included in this study. Clinical and laboratory data were obtained from the medical charts of the patients. Reverse transcription polymerase chain reaction (RT-PCR) using specific primers was employed to identify molecular rearrangements.
Results: At diagnosis, the median age was 33 years, and there was a predominance of males (61%). The most common immunophenotype was B lineage (76%). BCR-ABL rearrangements was detected in 14 (34%) patients with the following distribution: p190 (28%), p210 (50%) and double positive (22%). Overall survival of patients with a mean/median of 331/246 days of follow up was 39%, respectively, negative BCR-ABL (44%) and positive BCR-ABL (28%).
Conclusion: These results confirm the high frequency of BCR-ABL rearrangements and the low survival rate of adult Brazilian patients with acute lymphoblastic leukemia.
(Copyright © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze: MEDLINE
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