Identification of the best cutoff points and clinical signs specific for early recognition of macrophage activation syndrome in active systemic juvenile idiopathic arthritis.

Autor: Kostik MM; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia. Electronic address: mikhail.kostik@gmail.com., Dubko MF; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Masalova VV; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Snegireva LS; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Kornishina TL; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Chikova IA; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Likhacheva TS; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Isupova EA; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Glebova NI; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Kuchinskaya EM; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Balbotkina EV; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Buchinskaya NV; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Kalashnikova OV; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia., Chasnyk VG; Hospital Pediatry, Saint-Petersburg State Pediatric Medical University of Ministry of Healthcare of the Russia, 194100, Litovskaya 2, Saint-Petersburg, Russia.
Jazyk: angličtina
Zdroj: Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2015 Feb; Vol. 44 (4), pp. 417-22. Date of Electronic Publication: 2014 Sep 11.
DOI: 10.1016/j.semarthrit.2014.09.004
Abstrakt: Objectives: The purpose of our study was to detect early clinical and laboratory signs that help to discriminate macrophage activation syndrome (MAS) from active systemic juvenile idiopathic arthritis (SJIA) without MAS.
Methods: Our retrospective study was based on reviewing the medical charts of the children admitted to the rheumatology department with active SJIA and definite MAS (n = 18) and without MAS (n = 40). We evaluated the data related to SJIA and MAS at the moment of the patient׳s admission. If the patient had signs of MAS since admission or developed definite MAS later during this flare, he was referred to the main group. The children who did not have MAS during the flare episode and did not have MAS in the past medical history were in the control group. We calculated the cutoff points for MAS parameters, performed the analysis of sensitivity and specificity, identified the predictors, and provided the preliminary diagnostic rule through "the-number-of-criteria-present" approach.
Results: The clinical signs were relevant to MAS in SJIA: oligoarticular disease course (OR = 5.6), splenomegaly (OR = 67.6), hemorrhages (OR = 33.0), and respiratory failure (OR = 11.3). The involvement of wrist (OR = 0.2), MCP (OR = 0.1), and PIP joints (OR = 0.1) was protective against MAS development. The best cutoffs for laboratory parameters were PLT ≤ 211 × 10(9)/l, WBC ≤ 9.9 × 10(9)/l, AST > 59.7U/l, LDH > 882U/l, albumin ≤ 2.9g/dl, ferritin > 400μg/l, fibrinogen ≤ 1.8g/l, and proteinuria. The laboratory variables were more precise in the discrimination of early MAS than clinical: any 3 or more laboratory criteria provided the highest specificity (1.0) and sensitivity (1.0) and OR = 2997.
Conclusions: We detected clinical and laboratory markers and created preliminary diagnostic (laboratory) guidelines for early discrimination of MAS in active SJIA.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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