| Autor: |
Gilbertsen RB; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105., Cullinen KM, Wilburn DJ, Dong MK, Conroy MC |
| Jazyk: |
angličtina |
| Zdroj: |
Agents and actions [Agents Actions] 1989 Jun; Vol. 27 (3-4), pp. 303-5. |
| DOI: |
10.1007/BF01972805 |
| Abstrakt: |
CI-949 (5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H -indole- 2-carboxamide, L-arginine salt), an antiallergy compound, was found to be a weak inhibitor of IL-1 release from LPS-stimulated murine peritoneal exudate cells and human peripheral blood leukocytes, with IC50S of 186.2 and 267.9 microM, respectively. CI-949 was also a poor inhibitor of release of IL-2 from Con A-stimulated rat splenocytes (37% inhibition at 100 microM). CI-949 did produce concentration-related inhibition of the response of human lymphocytes to PHA and Con A (IC50S = 44.7 and 21.5 microM, respectively) as well as in the mixed lymphocyte reaction (MLR) (IC50 = 16.8 microM). The clinical significance of these latter findings is unknown at present. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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