B-cell hyperactivity in murine lupus I. Immunological abnormalities in lupus-prone strains and the activation of normal B cells.
| Autor: | Theofilopoulos AN; Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA., Prud'homme GJ, Fieser TM, Dixon FJ |
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| Jazyk: | angličtina |
| Zdroj: | Immunology today [Immunol Today] 1983 Oct; Vol. 4 (10), pp. 287-91. |
| DOI: | 10.1016/0167-5699(83)90138-X |
| Abstrakt: | B-cell hyperactivity is the general and cardinal feature of murine and human systemic lupus erythematosus (SLE), the prototype organ-non-specific autoimmune disease. The defect(s) responsible could be intrinsic to B cells, secondary to T-cell or macrophage abnormalities resulting in excessive help or deficient suppression, or could stem f rom qualitative/quantitative abnormalities of autoantigens. Here Argyrios Theofilopoulos and his colleagues review the immunopathological and cellular abnormalities observed in murine lupus and the factors currently thought to play a role in normal B-cell proliferation, differentiation and Ig class switching. Next month, in a second article, they discuss abnormalities in B-cell response to and/or overproduction of T-cell-derived accessory signals which may explain the generalized B-cell hyperactivity associated with mouse and human lupus. (Copyright © 1983. Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
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