Liquid-liquid phase separation in biology.

Autor: Hyman AA; Max Planck Institute of Molecular Cell Biology and Genetics Dresden, and., Weber CA, Jülicher F
Jazyk: angličtina
Zdroj: Annual review of cell and developmental biology [Annu Rev Cell Dev Biol] 2014; Vol. 30, pp. 39-58.
DOI: 10.1146/annurev-cellbio-100913-013325
Abstrakt: Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.
Databáze: MEDLINE