Preoperative platelet dysfunction predicts blood product transfusion in children undergoing cardiac surgery.

Autor:	Zubair MM; Division of Pediatric Cardiac Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR, USA., Bailly DK; Division of Pediatric Cardiology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA., Lantz G; Division of Pediatric Cardiac Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR, USA., Sunstrom RE; Division of Pediatric Cardiac Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR, USA., Saharan S; Division of Pediatric Cardiology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA., Boshkov LK; Division of Hematology, Department of Medicine, Oregon Health & Science University, Portland, OR, USA., Sochacki P; Division of Hematology, Department of Medicine, Oregon Health & Science University, Portland, OR, USA., Roger Hohimer A; Perinatal Division, Department of Obstetrics, Oregon Health & Science University, Portland, OR, USA., Lasarev MR; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA., Langley SM; Division of Pediatric Cardiac Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR, USA langleys@ohsu.edu.
Jazyk:	angličtina
Zdroj:	Interactive cardiovascular and thoracic surgery [Interact Cardiovasc Thorac Surg] 2015 Jan; Vol. 20 (1), pp. 24-30. Date of Electronic Publication: 2014 Oct 03.
DOI:	10.1093/icvts/ivu315
Abstrakt:	Objectives: Excessive bleeding can be a problem during or after cardiac surgery. While cardiopulmonary bypass-associated platelet dysfunction is an important inducer of coagulopathy, preoperative platelet dysfunction can also contribute to this bleeding. We investigated the relationship between preoperative platelet dysfunction and transfusion of blood products given to children undergoing cardiac surgery. Methods: The platelet function analyser test measures platelet function in vitro by aspirating blood through a small standard hole (creating high shear) in a collagen membrane infused with a platelet agonist. The time taken to form a platelet plug is known as closure time and prolonged closure time (CT) indicates platelet dysfunction. Three hundred and thirty-eight children who had undergone surgery with cardiopulmonary bypass between 2008 and 2012 were included. The volume of red blood cells and fresh-frozen plasma transfused was recorded. The relationship between closure time and transfusion requirements was analysed using linear and logistic regression. Results: Patients with prolonged closure time had greater odds of getting red blood cells and fresh-frozen plasma transfusions compared with patients with normal closure time (P <0.01). On univariate analysis, age, weight, haematocrit, cardiopulmonary bypass time, Risk Adjustment for Congenital Heart Surgery score and closure time were associated with increased odds of red blood cells and fresh-frozen plasma transfusion in the operation theatre (P <0.05). However, when logistic multivariable regression analysis was applied, only age, cardiopulmonary bypass time and closure time remained as significant predictive factors for transfusion. Conclusions: In children who have undergone cardiac surgery, when age and cardiopulmonary bypass time are accounted for, a prolonged preoperative closure time is significantly associated with increased odds of red blood cells and fresh-frozen plasma transfusion in the operation theatre. This may have implications for planning and utilization of blood products. (© The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
Databáze:	MEDLINE
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