Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

Autor:	Skibola CF; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA. Electronic address: cskibola@uab.edu., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Vijai J; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Conde L; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA., Wang Z; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA., Yeager M; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA., de Bakker PI; Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht 3584 CG, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands., Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Vajdic CM; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia., Foo JN; Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore., Bracci PM; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA., Vermeulen RC; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands; Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands., Slager SL; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA., de Sanjose S; Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain., Wang SS; Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, CA 91030, USA., Linet MS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Salles G; Department of Hematology, Hospices Civils de Lyon, Pierre benite Cedex 69495, France; Department of Hematology, Université Lyon-1, Pierre benite Cedex 69495, France; Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France., Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Severi G; Human Genetics Foundation, Turin 10126, Italy; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia., Hjalgrim H; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark., Lightfoot T; Department of Health Sciences, University of York, York YO10 5DD, UK., Melbye M; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Gu J; Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA., Ghesquières H; Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France; Department of Hematology, Centre Léon Bérard, Lyon 69008, France., Link BK; Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Holly EA; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA., Smith A; Department of Health Sciences, University of York, York YO10 5DD, UK., Tinker LF; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA., Teras LR; Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA., Kricker A; Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia., Becker N; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany., Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Spinelli JJ; Cancer Control Research, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada; School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Zhang Y; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC 3010, Australia., Vineis P; Human Genetics Foundation, Turin 10126, Italy; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK., Monnereau A; Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France; UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France; Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux Cedex 33076, France., Bertrand KA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Zeleniuch-Jacquotte A; Department of Population Health, New York University School of Medicine, New York, NY 10016, USA; Cancer Institute, New York University School of Medicine, New York, NY 10016, USA., Gabbas A; Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy., Chung CC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Burdett L; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA., Hutchinson A; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA., Lawrence C; Health Studies Sector, Westat, Rockville, MD 20850, USA., Montalvan R; Health Studies Sector, Westat, Rockville, MD 20850, USA., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Ma B; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China., Liu J; Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore., Adami HO; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Glimelius B; Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm 17176, Sweden; Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala 75105, Sweden., Ye Y; Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA., Nowakowski GS; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA., Dogan A; Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Thompson CA; Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Habermann TM; Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Novak AJ; Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Liebow M; Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Witzig TE; Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Weiner GJ; Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Schenk M; Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI 48201, USA., Hartge P; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., De Roos AJ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA; Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA 19104, USA., Cozen W; Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Zhi D; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Akers NK; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA., Riby J; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA., Smith MT; Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA 94720, USA., Lacher M; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Villano DJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Maria A; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Roman E; Department of Health Sciences, University of York, York YO10 5DD, UK., Kane E; Department of Health Sciences, University of York, York YO10 5DD, UK., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH 43210, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Diver WR; Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA., Turner J; Department of Anatomical Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia; Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, NSW 2113, Australia., Armstrong BK; Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia., Benavente Y; Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain., Boffetta P; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Brennan P; Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 656 53, Czech Republic., Maynadie M; EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France., Staines A; School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland., McKay J; Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer, Lyon 69372, France., Brooks-Wilson AR; Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada., Zheng T; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA., Holford TR; Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA., Chamosa S; Health Department, BioDonostia Research Institute, Basque Region 20014, Spain., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany., Kelly RS; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Ohlsson B; Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö 205 02, Sweden., Travis RC; Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK., Weiderpass E; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika 9037, Norway; Cancer Registry of Norway, Oslo 0304, Norway; Department of Genetic Epidemiology, Folkhalsan Research Center, Helsinki 00250, Finland., Clavel J; Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France; UMRS 1018, Université Paris Sud, Villejuif Cedex 94807, France., Giovannucci E; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Kraft P; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Virtamo J; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00271, Finland., Mazza P; Department of Hematology, Ospedale Nord, Taranto 74100, Italy., Cocco P; Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy., Ennas MG; Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy., Chiu BC; Department of Health Studies, University of Chicago, Chicago, IL 60637, USA., Fraumeni JF Jr; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Nieters A; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany., Offit K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Wu X; Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA., Cerhan JR; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA., Smedby KE; Department of Medicine Solna, Karolinska Institutet, Stockholm 17176, Sweden., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Jazyk:	angličtina
Zdroj:	American journal of human genetics [Am J Hum Genet] 2014 Oct 02; Vol. 95 (4), pp. 462-71.
DOI:	10.1016/j.ajhg.2014.09.004
Abstrakt:	Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. (Copyright © 2014 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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