| Autor: |
Brandtzaeg P; Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), University of Oslo, Norway., Bosnes V, Halstensen TS, Scott H, Sollid LM, Valnes KN |
| Jazyk: |
angličtina |
| Zdroj: |
Scandinavian journal of immunology [Scand J Immunol] 1989 Jul; Vol. 30 (1), pp. 123-8. |
| DOI: |
10.1111/j.1365-3083.1989.tb01196.x |
| Abstrakt: |
A revived interest in intraepithelial lymphocytes (IEL) has been elicited by several recent reports suggesting that murine and avian intestinal epithelium contains mainly CD3+CD8+ cells expressing the gamma/delta T-cell receptor (TcR) for antigen; this contrasts with systemically distributed T cells which preferentially employ the TcR alpha/beta. An anatomical dichotomy in the distribution of these two T-cell lineages has hence been proposed. Here we report that this concept does not hold true in man. In situ studies with monoclonal TcR-framework antibodies showed that most (70-90%) human intestinal IEL (which are mainly CD3+CD8+) expressed TcR alpha/beta. Moreover, almost half of the intraepithelial CD3+ cells were positive for the smallest (180 kDa) CD45 molecule (UCHL1); this probably reflected that they are antigen-primed and thus represent traditional CD3+CD8+ alpha/beta+ memory T cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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