Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile and neurohumoral axis in hypertensive women at reproductive age.

Autor: de Morais TL; Universidade Nove de Julho (UNINOVE), São Paulo, Brazil., Giribela C; Hypertension Unit, Heart Institute (InCor), University of São Paulo, São Paulo, Brazil; Gynecology Department, University of São Paulo, São Paulo, Brazil., Nisenbaum MG; Gynecology Department, University of São Paulo, São Paulo, Brazil., Guerra G; Hypertension Unit, Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Mello N; Gynecology Department, University of São Paulo, São Paulo, Brazil., Baracat E; Gynecology Department, University of São Paulo, São Paulo, Brazil., Consolim-Colombo FM; Universidade Nove de Julho (UNINOVE), São Paulo, Brazil; Hypertension Unit, Heart Institute (InCor), University of São Paulo, São Paulo, Brazil. Electronic address: fernanda.consolim@uninove.br.
Jazyk: angličtina
Zdroj: European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2014 Nov; Vol. 182, pp. 113-7. Date of Electronic Publication: 2014 Sep 16.
DOI: 10.1016/j.ejogrb.2014.09.006
Abstrakt: Unlabelled: The use of combined oral contraceptives is widespread among hypertensive women despite being associated with increased cardiovascular risk. Contraceptives containing drospirenone, which has antimineralocorticoid properties, may have a positive or neutral effect on neurohumoral activation and metabolic homeostasis of hypertensive women at reproductive age.
Objectives: To evaluate the effect of combined oral contraceptive containing drospirenone+ethinylestradiol on the systemic blood pressure, metabolic variables and neurohumoral axis in hypertensive women in reproductive age.
Design: Prospective controlled trial with 56 hypertensive women allocated in two groups: 30 volunteers under oral combined contraceptive use and 26 volunteers using non-hormonal contraceptive methods. Subjects were tested before the introduction of the contraceptive method and 6 months after its use. For data acquisition, we used continuous non-invasive beat-to-beat blood pressure curve recordings and, for the biochemical and hormonal analyses two blood samples were obtained. Student's t test was used to determine differences between groups and moments and p<0.05 was considered statistically significant.
Results: Comparing antropometric and blood pressure measurements, cardiac sympatho-vagal modulation, baroreceptor sensitivity, metabolic and neurohumoral axis variables between baseline and after 6 months, no significant difference was detected in each group or between groups. Except serum triglyceride levels which increased in the group of women using EE+DRSP after 6 months of use.
Conclusion: A contraceptive containing 20 mcg of ethinyl estradiol and 3 mg of drospirenone causes no significant changes in clinical and autonomic parameters, metabolic variables and neurohumoral axis of hypertensive women.
(Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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