| Autor: |
Afonin KA; Basic Research Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States., Viard M, Koyfman AY, Martins AN, Kasprzak WK, Panigaj M, Desai R, Santhanam A, Grabow WW, Jaeger L, Heldman E, Reiser J, Chiu W, Freed EO, Shapiro BA |
| Jazyk: |
angličtina |
| Zdroj: |
Nano letters [Nano Lett] 2014 Oct 08; Vol. 14 (10), pp. 5662-71. Date of Electronic Publication: 2014 Sep 30. |
| DOI: |
10.1021/nl502385k |
| Abstrakt: |
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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