Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.

Autor: Kutilin DS; South Federal University, Rostov-on-Don, Russia., Bondarenko TI, Kornienko IV, Mikhaleva II
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2014 Sep; Vol. 157 (5), pp. 616-9. Date of Electronic Publication: 2014 Sep 26.
DOI: 10.1007/s10517-014-2628-4
Abstrakt: Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells. The expression of these genes was shown to decrease during physiological aging of the body.
Databáze: MEDLINE