Concluding the amyloid formation pathway of a coiled-coil-based peptide from the size of the critical nucleus.
| Autor: | Gerling UI; Department of Chemistry and Biochemistry-Organic Chemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany)., Miettinen MS, Koksch B |
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| Jazyk: | angličtina |
| Zdroj: | Chemphyschem : a European journal of chemical physics and physical chemistry [Chemphyschem] 2015 Jan 12; Vol. 16 (1), pp. 108-14. Date of Electronic Publication: 2014 Sep 26. |
| DOI: | 10.1002/cphc.201402400 |
| Abstrakt: | The size of the critical nucleus acting as intermediate in the amyloid formation of a model peptide is calculated. The theoretical approach is based on experimentally determined amyloid formation rates and gives new insights into the amyloid formation pathway. (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
| Databáze: | MEDLINE |
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