| Autor: |
Hemmick LM; Department of Pharmacology, University of Rochester School of Medicine and Dentistry, NY 14642., Bidlack JM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroimmunology [J Neuroimmunol] 1989 Jun; Vol. 23 (1), pp. 67-71. |
| DOI: |
10.1016/0165-5728(89)90074-x |
| Abstrakt: |
The opioid peptide beta h-endorphin 1-31 inhibited the plaque-forming cell (PFC) response to sheep red blood cells when rat splenocytes, immunized in vivo, were cultured in vitro with the peptide. The opioid antagonist naloxone failed to reverse the beta h-endorphin 1-31 suppression of the PFC response. Peptide fragments of beta h-endorphin 1-31, other opioid peptides, and alkaloids had no effect on the response. These data indicate that beta h-endorphin 1-31 suppresses antibody production or secretion by a specific, non-opioid receptor on the rat splenocytes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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