Modifications in lipid levels are independent of serum TNF-α in rheumatoid arthritis: results of an observational 24-week cohort study comparing patients receiving etanercept plus methotrexate or methotrexate as monotherapy.

Autor: Rodriguez-Jimenez NA; Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), Guadalajara, JAL, Mexico., Garcia-Gonzalez CE; Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, JAL, Mexico., Ayala-Lopez KP; Departamento de Anestesiología, Hospital Regional de Zona 1, IMSS, Aguascalientes, AGS, Mexico., Trujillo-Hernandez B; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL, Mexico., Aguilar-Chavez EA; Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, JAL, Mexico ; Programa de Becarios en Investigacion en Salud, Unidad de Medicina Familiar 2, IMSS, Guadalajara, JAL, Mexico., Rocha-Muñoz AD; Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), Guadalajara, JAL, Mexico., Vasquez-Jimenez JC; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL, Mexico., Olivas-Flores E; Departamento de Anestesiología, Hospital General Regional 180, IMSS, Tlajomulco, JAL, Mexico., Salazar-Paramo M; Division de Investigacion en Salud, UMAE, Hospital de Especialidades, Centro Medico Nacional de Occidente, IMSS, Mexico., Corona-Sanchez EG; Departamento de Fisiologia, CUCS, U de G, Guadalajara, JAL, Mexico., Vazquez-Del Mercado M; Coordinacion de Posgrado, CUCS, U de G, Guadalajara, JAL, Mexico., Varon-Villalpando E; Departamento de Patologia Clinica, Hospital General Regional 110, IMSS, Guadalajara, JAL, Mexico., Cota-Sanchez A; Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, JAL, Mexico., Cardona-Muñoz EG; Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), Guadalajara, JAL, Mexico., Gamez-Nava JI; Unidad de Investigacion en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional de Occidente, IMSS, Guadalajara, JAL, Mexico., Gonzalez-Lopez L; Departamento de Medicina Interna-Reumatologia, Hospital General Regional 110, IMSS, 44716 Guadalajara, JAL, Mexico ; Programa de Doctorado en Salud Publica, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 510305. Date of Electronic Publication: 2014 Aug 27.
DOI: 10.1155/2014/510305
Abstrakt: Objective: To compare the modifications in lipids between patients with rheumatoid arthritis (RA) receiving etanercept plus methotrexate (ETA + MTX) versus methotrexate (MTX) and their relationship with serum levels of tumor necrosis factor-alpha (TNF-α).
Methods: In an observational cohort study, we compared changes in lipid levels in patients receiving ETA + MTX versus MTX in RA. These groups were assessed at baseline and at 4 and 24 weeks, measuring clinical outcomes, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and TNF-α.
Results: Baseline values for lipid levels were similar in both groups. HDL-C levels increased significantly only in the ETA + MTX group (from 45.5 to 50.0 mg/dL at 4 weeks, a 10.2% increase, P < 0.001, and to 56.0 mg/dL at 24 weeks, a 25.1% increase, P < 0.001), while other lipids underwent no significant changes. ETA + MTX also exhibited a significant increase in TNF-α (44.8 pg/mL at baseline versus 281.4 pg/mL at 24 weeks, P < 0.001). The MTX group had no significant changes in lipids or TNF-α. Significant differences in HDL-C between groups were observed at 24 weeks (P = 0.04) and also in TNF-α  (P = 0.01).
Conclusion: HDL-C levels increased significantly following treatment with ETA + MTX, without a relationship with decrease of TNF-α.
Databáze: MEDLINE
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