Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: a one-year pilot randomized controlled trial in adults with severe burns.

Autor: Rousseau AF; Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium. Electronic address: afrousseau@chu.ulg.ac.be., Foidart-Desalle M; Physical Medicine and Sport Traumatology Service, University of Liège, University Hospital, Liège, Belgium., Ledoux D; Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium., Remy C; Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium; Motility Science Department, University of Liège, Liège, Belgium., Croisier JL; Motility Science Department, University of Liège, Liège, Belgium., Damas P; Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium., Cavalier E; Clinical Chemistry Department, University of Liège, University Hospital, Liège, Belgium.
Jazyk: angličtina
Zdroj: Burns : journal of the International Society for Burn Injuries [Burns] 2015 Mar; Vol. 41 (2), pp. 317-25. Date of Electronic Publication: 2014 Sep 16.
DOI: 10.1016/j.burns.2014.07.005
Abstrakt: Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury.
Design: Monocentric randomized controlled trial.
Methods: Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol.
Results: Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37-61)ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity.
Conclusions: This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life.
(Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.)
Databáze: MEDLINE
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