Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.
| Autor: | Gaydos LJ; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA., Wang W; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Strome S; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. Department of Biology, Indiana University, Bloomington, IN 47405, USA. sstrome@ucsc.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Science (New York, N.Y.) [Science] 2014 Sep 19; Vol. 345 (6203), pp. 1515-8. Date of Electronic Publication: 2014 Sep 18. |
| DOI: | 10.1126/science.1255023 |
| Abstrakt: | For proper development, cells must retain patterns of gene expression and repression through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but its transmission is not well understood. Our studies suggest that PRC2 represses the X chromosomes in Caenorhabditis elegans germ cells, and this repression is transmitted to embryos by both sperm and oocytes. By generating embryos containing some chromosomes with and some without H3K27me, we show that, without PRC2, H3K27me is transmitted to daughter chromatids through several rounds of cell division. In embryos with PRC2, a mosaic H3K27me pattern persists through embryogenesis. These results demonstrate that H3K27me and PRC2 each contribute to epigenetically transmitting the memory of repression across generations and during development. (Copyright © 2014, American Association for the Advancement of Science.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|