Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness.

Autor: Walford HH; Department of Medicine, University of California-San Diego, San Diego, CA, USA; Rady's Children's Hospital of San Diego, Division of Rheumatology, Allergy and Immunology, San Diego, CA, USA., Lund SJ; Department of Medicine, University of California-San Diego, San Diego, CA, USA., Baum RE; Department of Medicine, University of California-San Diego, San Diego, CA, USA., White AA; Division of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, CA, USA., Bergeron CM; Division of Head and Neck Surgery, Scripps Green Hospital, La Jolla, CA, USA., Husseman J; Department of Surgery, Division of Otolaryngology, University of California-San Diego, San Diego, CA, USA., Bethel KJ; Division of Surgical Pathology, Scripps Green Hospital, La Jolla, CA, USA., Scott DR; Division of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, CA, USA., Khorram N; Department of Medicine, University of California-San Diego, San Diego, CA, USA., Miller M; Department of Medicine, University of California-San Diego, San Diego, CA, USA., Broide DH; Department of Medicine, University of California-San Diego, San Diego, CA, USA., Doherty TA; Department of Medicine, University of California-San Diego, San Diego, CA, USA. Electronic address: tdoherty@ucsd.edu.
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2014 Nov; Vol. 155 (1), pp. 126-135. Date of Electronic Publication: 2014 Sep 16.
DOI: 10.1016/j.clim.2014.09.007
Abstrakt: Group 2 innate lymphoid cells (ILC2s) have recently been identified in human nasal polyps, but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid use is unknown. Here, we show that eosinophilic nasal polyps contained double the number of ILC2s vs. non-eosinophilic polyps. Polyp ILC2s were also reduced by 50% in patients treated with systemic corticosteroids. Further, using a fungal allergen challenge mouse model, we detected greatly reduced Th2 cytokine-producing and Ki-67+ proliferating lung ILC2s in mice receiving dexamethasone. Finally, ILC2 Annexin V staining revealed extensive apoptosis after corticosteroid treatment in vivo and in vitro. Thus, ILC2s are elevated in the eosinophilic nasal polyp endotype and systemic corticosteroid treatment correlated with reduced polyp ILC2s. Finally, allergen-challenged mice showed reduced ILC2s and increased ILC2 apoptosis after corticosteroid treatment suggesting that ILC2 may be responsive to corticosteroids in eosinophilic respiratory disease.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: