Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection.

Autor:	Duppach J; Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany., Francois S; Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany., Joedicke JJ; Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany., Dittmer U; Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany., Kraft AR; Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany kraft.anke@mh-hannover.de.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2014 Dec; Vol. 88 (23), pp. 13892-6. Date of Electronic Publication: 2014 Sep 17.
DOI:	10.1128/JVI.01941-14
Abstrakt:	It is still unclear whether expanded and activated regulatory T cells (Tregs) in chronic viral infections can influence primary immune responses against superinfections with unrelated viruses. Expanded Tregs found in the spleens of chronically Friend virus (FV)-infected mice decreased murine cytomegalovirus (mCMV)-specific CD8(+) T cell responses during acute mCMV superinfection. This suppression of mCMV-specific T cell immunity was found only in organs with FV-induced Treg expansion. Surprisingly, acute mCMV infection itself did not expand or activate Tregs. (Copyright © 2014, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
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