| Autor: |
Shaheen F, Rasoola S, Shah ZA, Soomro S, Jabeen A, Mesaik MA, Choudhary MI |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product communications [Nat Prod Commun] 2014 Jul; Vol. 9 (7), pp. 903-6. |
| Abstrakt: |
Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4'-O-(6"-O-p-coumaroyl)-beta-D-glucopyranoside (3), along with four known constituents 4-7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1-3 exhibited moderate to low level of inhibition on nitric oxide (NO.) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-alpha. The new constituents 1-3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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